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Article

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Cancer cell - 4 Aug 2009

Xiao Wenbin, Hong Hong, Kawakami Yuko, Kato Yuko, Wu Dianqing, Yasudo Hiroki, Kimura Akiko, Kubagawa Hiromi, Bertoli Luigi F, Davis Randall S, Chau Luan A, Madrenas Joaquin, Hsia Cyrus C, Xenocostas Anargyros, Kipps Thomas J, Hennighausen Lothar, Iwama Atsushi, Nakauchi Hiromitsu, Kawakami Toshiaki

Abstract excerpt

Given its catalytic activity to generate diacylglycerol and inositol 1,4,5-trisphosphate, phospholipase C (PLC) is implicated in promoting cell growth. However, we found that PLC-beta3-deficient mice develop myeloproliferative disease, lymphoma, and other tumors. The mutant mice have increased numbers of hematopoietic stem cells with increased proliferative, survival, and myeloid-differentiative abilities. These...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19647226
DOI: 10.1016/j.ccr.2009.05.018
PMCID: PMC2744338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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