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An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia

17 Sept 2021

Abstract excerpt

The contribution of the bone marrow (BM) immune microenvironment to acute myeloid leukemia (AML) development is well-known, but its prognostic significance is still elusive. Indoleamine 2,3-dioxygenase 1 (IDO1), which is negatively regulated by the BIN1 proto-oncogene, is an interferon-γ-inducible mediator of immune tolerance. With the aim to develop a prognostic IDO1-based immune gene signature, biological and...

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PMID: 34535017
DOI: 10.1182/bloodadvances.2021004878

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