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Article

Multiplex single-nucleotide polymorphism typing by nanoparticle-coupled DNA-templated reactions.

Journal of the American Chemical Society - 26 Aug 2009

Xue Xuejia, Xu Wei, Wang Feng, Liu Xiaogang

Abstract excerpt

A novel chip-based detection approach for single-nucleotide polymorphism (SNP) typing based on nanoparticle-coupled DNA-templated ligation reactions is reported. In contrast to conventional methods or recently developed techniques, this approach does not need costly instrumentation and complex stringency washing processes and offers both rapid multiplex SNP detection capability and ultrahigh sensitivity. The...

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PMID: 19642679
DOI: 10.1021/ja904728v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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