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Article

Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity.

Chemical communications (Cambridge, England) - 21 Oct 2012

Shen Wei, Deng Huimin, Teo Alan Kay Liang, Gao Zhiqiang

Abstract excerpt

Coupling gold nanoparticle-based ligation to a ligation chain reaction enables colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity. One mutant in 2000 copies of a wild-type gene can be detected in 20-100 pg of PCR-amplified genomic DNA samples.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22968418
DOI: 10.1039/c2cc35070j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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