Article
The functional cytotoxic T lymphocyte-associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer.
Cancer - 1 Oct 2012
Yang Ming, Sun Tong, Zhou Yifeng, Wang Li, Liu Li, Zhang Xiaojiao, Tang Xiaohu, Zhou Mo, Kuang Pengqun, Tan Wen, Li Hui, Yuan Qipeng, Yu Dianke
Abstract excerpt
BACKGROUND: Antitumor T lymphocytes play an essential part in immune surveillance of cancer cells. Cytotoxic T lymphocyte-associated Protein 4 (CTLA-4) is a negative regulator of T cell activation and proliferation and therefore influences immune surveillance of carcinogenesis of pancreas. Thus, this study examined the association between functional CTLA-4 49G-to-A (49G>A) single-nucleotide polymorphism and...
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