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Article

Quercetin and Baicalein Act as Potent Antiamyloidogenic and Fibril Destabilizing Agents for SOD1 Fibrils.

ACS chemical neuroscience - 15 Apr 2020

Bhatia Nidhi K, Modi Priya, Sharma Shilpa, Deep Shashank

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that has been associated with the deposition of aggregates of superoxide dismutase 1 (SOD1). Effective therapeutics against SOD1 fibrillation is still an area of active research. Herein, we demonstrate the potential of two naturally occurring flavonoids (quercetin and baicalein) to inhibit fibrillation of wild-type SOD1 with the aid of a...

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PMID: 32208672
DOI: 10.1021/acschemneuro.9b00677

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