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Article

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.

The Journal of biological chemistry - 18 Sept 2009

Radhakrishnan Anand, Stein Alexander, Jahn Reinhard, Fasshauer Dirk

Abstract excerpt

The synaptic vesicle protein synaptotagmin 1 is thought to convey the calcium signal onto the core secretory machinery. Its cytosolic portion mainly consists of two C2 domains, which upon calcium binding are enabled to bind to acidic lipid bilayers. Despite major advances in recent years, it is still debated how synaptotagmin controls the process of neurotransmitter release. In particular, there is disagreement...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19632983
DOI: 10.1074/jbc.M109.042499
PMCID: PMC2757977

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