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Article

Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism.

International journal of biological macromolecules - 1 Mar 2017

Tang Xia, Xie Chunliang, Wang Ying, Wang Xianchun

Abstract excerpt

Synaptotagmin I (Syt I) functions in the regulation of neurotransmitter release and multiple other cellular processes through its C2 domain binding to other molecules. Our previous study demonstrated that Rab3A, a small GTP-binding protein, is a new interacting partner of Syt I and could bind to both of the C2 domains; the polylysine motif in C2B is a key site for Rab3A binding, but the binding site on C2A is not...

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PMID: 28057568
DOI: 10.1016/j.ijbiomac.2016.12.074

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