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Article

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

The Journal of biological chemistry - 3 Nov 1995

Fukuda M, Kojima T, Aruga J, Niinobe M, Mikoshiba K

Abstract excerpt

Synaptotagmins I and II are inositol high polyphosphate series (inositol 1,3,4,5-tetrakisphosphate (IP4), inositol 1,3,4,5,6-pentakisphosphate, and inositol 1,2,3,4,5,6-hexakisphosphate) binding proteins, which are thought to be essential for Ca(2+)-regulated exocytosis of neurosecretory vesicles. In this study, we analyzed the inositol high polyphosphate series binding site in the C2B domain by site-directed...

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PMID: 7592870
DOI: 10.1074/jbc.270.44.26523

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