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Article

Interaction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.

Biophysical journal - 20 Oct 2010

Takahashi Hirohide, Shahin Victor, Henderson Robert M, Takeyasu Kunio, Edwardson J Michael

Abstract excerpt

Synaptotagmin I is the major Ca²(+) sensor for membrane fusion during neurotransmitter release. The cytoplasmic domain of synaptotagmin consists of two C2 domains, C2A and C2B. On binding Ca²(+), the tips of the two C2 domains rapidly and synchronously penetrate lipid bilayers. We investigated the forces of interaction between synaptotagmin and lipid bilayers using single-molecule force spectroscopy....

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Share to Calcium
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20959096
DOI: 10.1016/j.bpj.2010.08.047
PMCID: PMC2956219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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