Article
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005
Rhee J-S, Li L Y, Shin O-H, Rah J-C, Rizo J, Südhof T C, Rosenmund C
Abstract excerpt
Synaptotagmin 1 likely acts as a Ca2+ sensor in neurotransmitter release by Ca2+-binding to its two C2 domains. This notion was strongly supported by the observation that a mutation in the C2A domain causes parallel decreases in the apparent Ca2+ affinity of synaptotagmin 1 and in the Ca2+ sensitivity of release. However, this study was based on a single loss-of-function mutation. We now show that tryptophan...
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