Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder.

doi:10.1016/j.neulet.2003.10.043

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Article

Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder.

Neuroscience letters - 23 Jan 2004

Hong Chen-Jee, Lai I-Ching, Liou Ling-Ling, Tsai Shih-Jen

Abstract excerpt

The human alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) gene cluster maps to the chromosome 15q13-q14 and is implicated as a candidate gene for bipolar disorder (BPD) by genetic linkage study. A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene, which is located 1 Mb apart from CHRNA7. We tested the hypothesis that the allelic variant, 2 bp deletion (-2 bp), confers...

Topics

Adult
Base Pairing
Bipolar Disorder
Brain Chemistry
Chromosome Mapping
Chromosomes, Human, Pair 15
DNA Mutational Analysis
Female
Gene Frequency
Genes, Duplicate
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Genetic Variation

Genotype

Humans

Male

Nicotine

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 14729237
DOI: 10.1016/j.neulet.2003.10.043

Genes

CHRNA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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