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Article

Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder.

Neuroscience letters - 23 Jan 2004

Hong Chen-Jee, Lai I-Ching, Liou Ling-Ling, Tsai Shih-Jen

Abstract excerpt

The human alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) gene cluster maps to the chromosome 15q13-q14 and is implicated as a candidate gene for bipolar disorder (BPD) by genetic linkage study. A -2 bp deletion polymorphism has been found in the duplicated CHRNA7 (CHRNA7-like) gene, which is located 1 Mb apart from CHRNA7. We tested the hypothesis that the allelic variant, 2 bp deletion (-2 bp), confers...

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PMID: 14729237
DOI: 10.1016/j.neulet.2003.10.043

Genes

CHRNA7

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