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Article

Statistical classifiers for diagnosing disease from immune repertoires: a case study using multiple sclerosis

7 Sept 2017

Abstract excerpt

BACKGROUND: Deep sequencing of lymphocyte receptor repertoires has made it possible to comprehensively profile the clonal composition of lymphocyte populations. This opens the door for novel approaches to diagnose and prognosticate diseases with a driving immune component by identifying repertoire sequence patterns associated with clinical phenotypes. Indeed, recent studies support the feasibility of this,...

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PMID: 28882107
DOI: 10.1186/s12859-017-1814-6

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