Article
Mutation discovery in the mouse using genetically guided array capture and resequencing.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2009
D'Ascenzo Mark, Meacham Carl, Kitzman Jacob, Middle Christina, Knight Jim, Winer Roger, Kukricar Miroslav, Richmond Todd, Albert Thomas J, Czechanski Anne, Donahue Leah Rae, Affourtit Jason, Jeddeloh Jeffrey A, Reinholdt Laura
Abstract excerpt
Forward genetics (phenotype-driven approaches) remain the primary source for allelic variants in the mouse. Unfortunately, the gap between observable phenotype and causative genotype limits the widespread use of spontaneous and induced mouse mutants. As alternatives to traditional positional clon...
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