Article
High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs.
BMC genomics - 17 Aug 2009
Walter Nicole A R, Bottomly Daniel, Laderas Ted, Mooney Michael A, Darakjian Priscila, Searles Robert P, Harrington Christina A, McWeeney Shannon K, Hitzemann Robert, Buck Kari J
Abstract excerpt
BACKGROUND: Allelic variation is the cornerstone of genetically determined differences in gene expression, gene product structure, physiology, and behavior. However, allelic variation, particularly cryptic (unknown or not annotated) variation, is problematic for follow up analyses. Polymorphisms result in a high incidence of false positive and false negative results in hybridization based analyses and hinder the...
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