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Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2006

Caspary Tamara, Anderson Kathryn V

Abstract excerpt

Phenotype-based chemical mutagenesis screens for mouse mutations have undergone a transformation in the past five years from a potential approach to a practical tool. This change has been driven by the relative ease of identifying causative mutations now that the complete genome sequence is available. These unbiased screens make it possible to identify genes, gene functions and processes that are uniquely...

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PMID: 16724327
DOI: 10.1002/dvdy.20853

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