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Article

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival.

Leukemia & lymphoma - 1 Sept 2009

Paul Esbjörn, Paul Esbjörn, Uggla Bertil, Deneberg Stefan, Bengtzen Sofia, Hermansson Monica, Dahlman Ingrid, Rosenquist Richard, Wiman Klas G, Nahi Hareth

Abstract excerpt

The p14ARF protein activates the p53 tumor suppressor by binding to and inhibiting its negative regulator HDM-2. We have studied the prognostic impact of p14ARF in acute myeloid leukemia (AML). Leukemic cells from 57 adult patients with normal karyotype de novo AML were analyzed for p14ARF mRNA expression level using real-time polymerase chain reaction (RT-PCR). We also tested the effect of conventional...

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Share to Gene Expression Regulation, Leukemic
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Karyotyping

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

Share to Survival Analysis

Share to Transplantation, Homologous

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 19626541
DOI: 10.1080/10428190903111914

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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