Article
In acute myeloid leukemia, coexpression of at least two proteins, including P-glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat-shock protein 27, is predictive of the response to induction chemotherapy.
Experimental hematology - 1 Nov 1998
Kasimir-Bauer S, Ottinger H, Meusers P, Beelen D W, Brittinger G, Seeber S, Scheulen M E
Abstract excerpt
To identify prognostic factors alternative or additional to P-glycoprotein (Pgp), we studied the impact of the multidrug resistance-related protein (MRP), bcl-2 (flow cytometry), mutant p53 (single-strand conformation polymorphism), and heat-shock protein 27 (HSP27, Western blotting) in myeloid b...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Acute Disease
- Adult
- Aged
- Analysis of Variance
- Drug Resistance, Multiple
- Female
- Heat-Shock Proteins
- Humans
- Leukemia, Myeloid
- Male
- Middle Aged