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Article

Development of a human immunodeficiency virus type 1-based lentiviral vector that allows efficient transduction of both human and rhesus blood cells.

Journal of virology - 1 Oct 2009

Uchida Naoya, Washington Kareem N, Hayakawa Jun, Hsieh Matthew M, Bonifacino Aylin C, Krouse Allen E, Metzger Mark E, Donahue Robert E, Tisdale John F

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) vectors transduce rhesus blood cells poorly due to a species-specific block by TRIM5alpha and APOBEC3G, which target HIV-1 capsid and viral infectivity factor (Vif), respectively. We sought to develop a lentiviral vector capable of transducing both human and rhesus blood cells by combining components of both HIV-1 and simian immunodeficiency virus (SIV), including SIV...

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Share to Antigens, CD34
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Hematopoietic Stem Cells

Share to Lentivirus

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Share to Simian Immunodeficiency Virus

Share to Transduction, Genetic

Source

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Identifiers

PMID: 19625395
DOI: 10.1128/JVI.00357-09
PMCID: PMC2748003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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