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Article

Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors

4 Apr 2008

Abstract excerpt

Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors in nonhuman primates prior to clinical trials have been hampered by low transduction frequencies...

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PMID: 18388180
DOI: 10.1182/blood-2007-09-115022

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