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Article

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.

PloS one - 2 Nov 2009

Trobridge Grant D, Wu Robert A, Beard Brian C, Chiu Sum Ying, Muñoz Nina M, von Laer Dorothee, Rossi John J, Kiem Hans-Peter

Abstract excerpt

BACKGROUND: There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5Delta32) cells, setting the stage for transplantation of naturally resistant, or genetically modified stem cells as a viable therapy for AIDS. Hematopoietic stem cell (HSC) gene therapy...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19888329
DOI: 10.1371/journal.pone.0007693
PMCID: PMC2765621

Genes

MGMT
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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