Article
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.
Nature neuroscience - 1 Aug 2009
Bond Allison M, Vangompel Michael J W, Sametsky Evgeny A, Clark Mary F, Savage Julie C, Disterhoft John F, Kohtz Jhumku D
Abstract excerpt
Genomic studies demonstrate that, although the majority of the mammalian genome is transcribed, only about 2% of these transcripts are code for proteins. We investigated how the long, polyadenylated Evf2 noncoding RNA regulates transcription of the homeodomain transcription factors DLX5 and DLX6 in the developing mouse forebrain. We found that, in developing ventral forebrain, Evf2 recruited DLX and MECP2...
Topics
- Animals
- Gene Expression Regulation, Developmental
- Glutamate Decarboxylase
- Hippocampus
- Homeodomain Proteins
- Interneurons
- Methyl-CpG-Binding Protein 2
- Mice
- Mice, Knockout
- Mutation
- Neural Pathways
- Organ Culture Techniques
- RNA, Messenger