Article
DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency.
American journal of human genetics - 1 Sept 2007
Schüle Birgitt, Li Hong Hua, Fisch-Kohl Claudia, Purmann Carolin, Francke Uta
Abstract excerpt
Mutations in MECP2 and Mecp2 (encoding methyl-CpG binding protein 2 [MeCP2]) cause distinct neurological phenotypes in humans and mice, respectively, but the molecular pathology is unclear. Recent literature claimed that the developmental homeobox gene DLX5 is imprinted and that its imprinting status is modulated by MeCP2, leading to biallelic expression in Rett syndrome and twofold overexpression of Dlx5 and...
Topics
- Adult
- Aged
- Alleles
- Allelic Imbalance
- Animals
- Apoptosis Regulatory Proteins
- Base Sequence
- Cell Line
- Cerebral Cortex
- Chromosomes, Human, Pair 7
- DNA-Binding Proteins