Article
The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
Developmental biology - 1 Sept 2013
MacDonald Ryan B, Pollack Jacob N, Debiais-Thibaud Mélanie, Heude Eglantine, Talbot Jared Coffin, Ekker Marc
Abstract excerpt
During development of the mouse forebrain interneurons, the Dlx genes play a key role in a gene regulatory network (GRN) that leads to the GABAergic phenotype. Here, we have examined the regulatory relationships between the ascl1a, dlx, and gad1b genes in the zebrafish forebrain. Expression of ascl1a overlaps with dlx1a in the telencephalon and diencephalon during early forebrain development. The loss of Ascl1a...
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