Article
Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.
Pharmacogenetics and genomics - 1 Aug 2009
Aoki Masayo, Terada Tomohiro, Ogasawara Ken, Katsura Toshiya, Hatano Etsuro, Ikai Iwao, Inui Ken-Ichi
Abstract excerpt
OBJECTIVES: The aim of this study was to evaluate whether genetic polymorphisms are responsible for individual variation in the expression levels of hepatic organic anion transporters. METHODS: The mRNA levels of multidrug resistance-associated protein 2, organic anion transporting polypeptide (OATP) 1B1, OATP1B3 and OATP2B1 were determined by real-time polymerase chain reaction using liver tissue samples from...
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