Article
Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.
Journal of human genetics - 1 Jan 2008
Ogasawara Ken, Terada Tomohiro, Motohashi Hideyuki, Asaka Jun-Ichi, Aoki Masayo, Katsura Toshiya, Kamba Tomomi, Ogawa Osamu, Inui Ken-Ichi
Abstract excerpt
Organic cation transporters (OCTs) and organic anion transporters (OATs) (SLC22A family) play crucial roles in the renal secretion of various drugs. Messengar ribonucleic acid (mRNA) expression of transporters can be a key factor regulating interindividual differences in drug pharmacokinetics. However, the source of variations in mRNA levels of transporters is unclear. In this study, we focused on single...
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