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Article

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.

Journal of neurochemistry - 1 Feb 2007

Yang Zhe, Ney Agnieszka, Cromer Brett A, Ng Hooi-Ling, Parker Michael W, Lynch Joseph W

Abstract excerpt

The 5-hydroxytryptamine type-3 receptor antagonist tropisetron is in clinical use as an anti-emetic drug. This compound also exerts both potentiating and inhibitory effects on the glycine receptor chloride channel. The inhibitory effects occur at micromolar concentrations, whereas the potentiatin...

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Source

Identifiers

PMID: 17181559
DOI: 10.1111/j.1471-4159.2006.04242.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17181559-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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