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Article

Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.

Journal of neurochemistry - 1 Jun 2009

Maksay Gábor, Laube Bodo, Schemm Rudolf, Grudzinska Joanna, Drwal Malgorzata, Betz Heinrich

Abstract excerpt

Tropeines are bidirectional modulators of native and recombinant glycine receptors (GlyRs) and promising leads for the development of novel modulatory agents. Tropisetron potentiates and inhibits agonist-triggered GlyR currents at femto- to nanomolar and micromolar concentrations respectively. Here, the potentiating and inhibitory effects of another tropeine, 3alpha-(3'-methoxy-benzoyloxy)nortropane (MBN) were...

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PMID: 19383091
DOI: 10.1111/j.1471-4159.2009.06083.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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