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Article

Molecular determinants of ginkgolide binding in the glycine receptor pore.

Journal of neurochemistry - 1 Jul 2006

Hawthorne Rebecca, Cromer Brett A, Ng Hooi-Ling, Parker Michael W, Lynch Joseph W

Abstract excerpt

Ginkgolides are potent blockers of the glycine receptor Cl- channel (GlyR) pore. We sought to identify their binding sites by comparing the effects of ginkgolides A, B and C and bilobalide on alpha1, alpha2, alpha1beta and alpha2beta GlyRs. Bilobalide sensitivity was drastically reduced by incorporation of the beta subunit. In contrast, the sensitivities to ginkgolides B and C were enhanced by beta subunit...

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Identifiers

PMID: 16805834
DOI: 10.1111/j.1471-4159.2006.03875.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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