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Article

The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura.

Journal of neurology - 1 Dec 2006

Mazaheri Shahir, Hajilooi Mehrdad, Rafiei Alireza

Abstract excerpt

Migraine is considered to be a polygenic multifactorial disease with various environmental and genetic etiologies. Tumor necrosis factor-alpha (TNF-alpha), a potent immunomodulator and pro-inflammatory cytokine, has been implicated in many pathological processes in brain. The hypothesis of this study was that migraine without aura (MWA) might be associated with TNF-alpha (-308) polymorphism, resulting in...

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PMID: 17063315
DOI: 10.1007/s00415-006-0270-4

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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