Article
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
The Journal of biological chemistry - 2 Oct 2009
Nakano Toshiaki, Katafuchi Atsushi, Matsubara Mayumi, Terato Hiroaki, Tsuboi Tomohiro, Masuda Tasuku, Tatsumoto Takahiro, Pack Seung Pil, Makino Keisuke, Croteau Deborah L, Van Houten Bennett, Iijima Kenta, Tauchi Hiroshi, Ide Hiroshi
Abstract excerpt
DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. The steric hindrance imposed by cross-linked proteins (CLPs) will hamper DNA transactions, such as replication and transcription, posing an enormous threat to cells. In bacteria, DPCs with small CLPs are eliminated by nucleotide excision repair (NER), whereas oversized DPCs are processed exclusively by RecBCD-dependent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.