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Chromatin remodeling gene EZH2 involved in the genetic etiology of autism in Chinese Han population.

Neuroscience letters - 1 Jan 2016

Li Jun, You Yang, Yue Weihua, Yu Hao, Lu Tianlan, Wu Zhiliu, Jia Meixiang, Ruan Yanyan, Liu Jing, Zhang Dai, Wang Lifang

Abstract excerpt

Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders. Epigenetic factors play a critical role in the etiology of ASD. Enhancer of zest homolog 2 (EZH2), which encodes a histone methyltransferase, plays an important role in the process of chromatin remodeling during neurodevelopment. Further, EZH2 is located in chromosome 7q35-36, which is one of the linkage regions for autism. However,...

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PMID: 26552012
DOI: 10.1016/j.neulet.2015.10.074

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