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Article

No KRAS mutations found in gastrointestinal stromal tumors (GISTs): molecular genetic study of 514 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2013

Lasota Jerzy, Xi Liqiang, Coates Tiffany, Dennis RaShonda, Evbuomwan Moses O, Wang Zeng-Feng, Raffeld Mark, Miettinen Markku

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. A great majority of GISTs is driven by pathological activation of KIT or platelet-derived growth factor receptor-α (PDGFRA), two closely related receptor tyrosine kinases. However, other genetic changes including gain-of-function BRAF mutations and loss of succinate dehydrogenase (SDH) complex activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23702733
DOI: 10.1038/modpathol.2013.89
PMCID: PMC7560948

Genes

KRAS
KIT
PDGFRA
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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