Article
Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis.
The American journal of pathology - 1 Aug 2009
Okudela Koji, Yazawa Takuya, Woo Tetsukan, Sakaeda Masashi, Ishii Jun, Mitsui Hideaki, Shimoyamada Hiroaki, Sato Hanako, Tajiri Michihiko, Ogawa Nobuo, Masuda Munetaka, Takahashi Takashi, Sugimura Haruhiko, Kitamura Hitoshi
Abstract excerpt
Our preliminary studies revealed that oncogenic KRAS (KRAS/V12) dramatically suppressed the growth of immortalized airway epithelial cells (NHBE-T, with viral antigen-inactivated p53 and RB proteins). This process appeared to be a novel event, different from the so-called premature senescence that is induced by either p53 or RB, suggesting the existence of a novel tumor suppressor that functions downstream of...
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