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Article

GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.

Neuron - 16 Jul 2009

Sen Nilkantha, Hara Makoto R, Ahmad Abdullah Shafique, Cascio Matthew B, Kamiya Atsushi, Ehmsen Jeffrey T, Agrawal Nishant, Aggrawal Nishant, Hester Lynda, Doré Sylvain, Snyder Solomon H, Sawa Akira

Abstract excerpt

We recently reported a cell death cascade whereby cellular stressors activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus. The nuclear GAPDH/Siah complex augments p300/CBP-associated acetylation of nuclear proteins, including p53, which mediate cell death. We report a 52 kDa cytosolic protein, GOSPEL, which physiologically binds GAPDH, in...

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Source

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Identifiers

PMID: 19607794
DOI: 10.1016/j.neuron.2009.05.024
PMCID: PMC2758064

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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