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Article

Neuronal necrosis is regulated by a conserved chromatin-modifying cascade

8 Sept 2014

Abstract excerpt

Neuronal necrosis induced by calcium overload causes devastating brain dysfunction in diseases such as stroke and brain trauma. It has been considered a stochastic event lacking genetic regulation, and pharmacological means to suppress neuronal necrosis are lacking. Using a Drosophila model of calcium overloading, we found JIL-1/mitogen- and stress-activated protein kinase 1/2 is a regulator of neuronal necrosis...

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PMID: 25201987
DOI: 10.1073/pnas.1413644111

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