Article
Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.
The American journal of clinical nutrition - 1 Sept 2009
Junyent Mireia, Parnell Laurence D, Lai Chao-Qiang, Lee Yu-Chi, Smith Caren E, Arnett Donna K, Tsai Michael Y, Kabagambe Edmond K, Straka Robert J, Province Michael, An Ping, Borecki Ingrid, Ordovás José M
Abstract excerpt
BACKGROUND: Several genome-wide association studies have identified novel loci (KCTD10, MVK, and MMAB) that are associated with HDL-cholesterol concentrations. Of the environmental factors that determine HDL cholesterol, high-carbohydrate diets have been shown to be associated with low concentrations. OBJECTIVE: The objective was to evaluate the associations of 8 single nucleotide polymorphisms (SNPs) located...
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