Article
Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women.
The Journal of nutrition - 1 May 2009
Junyent Mireia, Arnett Donna K, Tsai Michael Y, Kabagambe Edmond K, Straka Robert J, Province Michael, An Ping, Lai Chao-Qiang, Parnell Laurence D, Shen Jian, Lee Yu-Chi, Borecki Ingrid, Ordovás Jose M
Abstract excerpt
The scaffolding protein PDZ domain containing 1 (PDZK1) regulates the HDL receptor scavenger receptor class B type I. However, the effect of PDZK1 genetic variants on lipids and metabolic syndrome (MetS) traits remains unknown. This study evaluated the association of 3 PDZK1 single nucleotide polymorphisms (SNP) (i33968C > T, i15371G > A, and i19738C > T) with lipids and risk of MetS and their potential...
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