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Article

Adenovirus E4-34kDa requires active proteasomes to promote late gene expression.

Virology - 10 Oct 2003

Corbin-Lickfett Kara A, Bridge Eileen

Abstract excerpt

A complex of the Adenovirus (Ad) early region 1b 55-kDa protein (E1b-55kDa) and the early region 4 ORF6 34-kDa protein (E4-34kDa) promotes viral late RNA accumulation in the cytoplasm while inhibiting the transport of most newly synthesized cellular mRNA. The E4 ORF3 11-kDa protein (E4-11kDa) functionally compensates for at least some of the activities of this complex. We find that the same large central region...

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PMID: 14592775
DOI: 10.1016/s0042-6822(03)00527-0

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