Article
Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography.
Clinical immunology (Orlando, Fla.) - 1 Oct 2009
Heron M, Grutters J C, Van Moorsel C H M, Ruven H J T, Kazemier K M, Claessen A M E, Van den Bosch J M M
Abstract excerpt
The integrin alpha(E)beta(7) is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the alpha(E) (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The -1088 A/G polymorphism was associated with sarcoidosis (P=0.004). An increased risk of disease was found...
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