Article
Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis.
Respiration; international review of thoracic diseases - 1 Jan 2000
Handa Tomohiro, Nagai Sonoko, Ito Isao, Tabuena Rollin, Shigematsu Michio, Hamada Kunio, Kitaichi Masanori, Izumi Takateru, Aoyama Tomoki, Toguchida Junya, Mishima Michiaki
Abstract excerpt
BACKGROUND: B7 proteins (CD80, CD86) are costimulatory molecules expressed on antigen-presenting cells and are essential factors for T cell activation. OBJECTIVES: The aim of this study is to investigate the relationship of B7 gene polymorphisms either to disease susceptibility or to cell profile of bronchoalveolar lavage (BAL) fluid in Japanese sarcoidosis patients. METHODS: Gene polymorphisms located in CD80...
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