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Are there any more ovarian tumor suppressor genes? A new perspective using ultra high-resolution copy number and loss of heterozygosity analysis.

Genes, chromosomes & cancer - 1 Oct 2009

Gorringe Kylie L, Ramakrishna Manasa, Williams Louise H, Sridhar Anita, Boyle Samantha E, Bearfoot Jennifer L, Li Jason, Anglesio Michael S, Campbell Ian G

Abstract excerpt

Ovarian cancer is characterized by complex genetic alterations, including copy number loss and copy number-neutral loss of heterozygosity (LOH). These alterations are assumed to represent the "second hit" of the underlying tumor suppressor gene (TSG), however, relative to the number of LOH hotspots reported, few ovarian TSGs have been identified. We conducted a high-resolution LOH analysis using SNP arrays (500K...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19603523
DOI: 10.1002/gcc.20694

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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