Article
Towards the elucidation of molecular determinants of cooperativity in the liver bile acid binding protein.
Proteins - 15 Nov 2009
Pedò Massimo, D'Onofrio Mariapina, Ferranti Pasquale, Molinari Henriette, Assfalg Michael
Abstract excerpt
Bile acid binding proteins (BABPs) are cytosolic lipid chaperones contributing to the maintenance of bile acid homeostasis and functional distribution within the cell. Liver BABPs act in parallel with ileal transporters to ensure vectorial transport of bile salts in hepatocytes and enterocytes, respectively. We describe the investigation of ligand binding to liver BABP, an essential step in the understanding of...
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