Article
Molecular differences between human liver fatty acid binding protein and its T94A variant in their unbound and lipid-bound states.
Biochimica et biophysica acta. Proteins and proteomics - 1 Sept 2017
D'Onofrio Mariapina, Barracchia Carlo Giorgio, Bortot Andrea, Munari Francesca, Zanzoni Serena, Assfalg Michael
Abstract excerpt
Liver fatty acid binding protein (L-FABP) is an abundant cytosolic protein playing a central role in intracellular lipid trafficking. The L-FABP T94A variant, originating from one of the most common polymorphisms in the FABP family, is associated with several lipid-related disorders. However, the molecular factors that determine the observed functional differences are currently unknown. In our work, we performed...
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