Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of ligand-induced folding of a natively unfolded helixless variant of rabbit I-BABP.

Biochemistry - 11 Aug 2009

Rea Anita M, Thurston Victoria, Searle Mark S

Abstract excerpt

Substitution of the helix-turn-helix capping motif (residues 9-35) of rabbit I-BABP with a flexible Gly-Gly-Ser-Gly linker results in the loss of stabilizing hydrophobic contacts and renders the beta-clamshell structure of this steroidal bile acid transport protein unfolded. However, in the presence of a bile acid ligand, we observe strong coupling between binding and folding, resulting in an enthalpy-driven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fatty Acid-Binding Proteins
Share to Helix-Turn-Helix Motifs
Share to Hydrophobic and Hydrophilic Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Protein Folding

Share to Protein Stability

Share to Rabbits

Share to Structural Homology, Protein

Source

Identifiers

PMID: 19580252
DOI: 10.1021/bi900805s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of ligand-induced folding of a natively unfolded helixless variant of rabbit I-BABP.PMID 19580252Read ↗

Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold.Semantic proximity Read ↗

Early folding events protect aggregation-prone regions of a β-rich protein.Semantic proximity Read ↗

Transporter-to-trap conversion: a disulfide bond formation in cellular retinoic acid binding protein I mutant triggered by retinoic acid binding irreversibly locks the ligand inside the protein.Semantic proximity Read ↗

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein.Semantic proximity Read ↗

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotypeSemantic proximity Read ↗

Transient folding intermediates characterized by protein engineering.Semantic proximity Read ↗

The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state.Semantic proximity Read ↗

The kinetic pathway of folding of barnase.Semantic proximity Read ↗

Conformation of the mineralocorticoid receptor N-terminal domain: evidence for induced and stable structure.Semantic proximity Read ↗

Helical propensity in an intrinsically disordered protein accelerates ligand binding.Semantic proximity Read ↗

Ligand Entry into Fatty Acid Binding Protein via Local Unfolding instead of Gap WideningSemantic proximity Read ↗

Structural characterization of the transition state for folding of muscle acylphosphatase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.