Article
Underlying genetic models of inheritance in established type 2 diabetes associations.
American journal of epidemiology - 1 Sept 2009
Salanti Georgia, Southam Lorraine, Altshuler David, Ardlie Kristin, Barroso Inês, Boehnke Michael, Cornelis Marilyn C, Frayling Timothy M, Grallert Harald, Grarup Niels, Groop Leif, Hansen Torben, Hattersley Andrew T, Hu Frank B, Hveem Kristian, Illig Thomas, Kuusisto Johanna, Laakso Markku, Langenberg Claudia, Lyssenko Valeriya, McCarthy Mark I, Morris Andrew, Morris Andrew D, Palmer Colin N A, Payne Felicity, Platou Carl G P, Scott Laura J, Voight Benjamin F, Wareham Nicholas J, Zeggini Eleftheria, Ioannidis John P A
Abstract excerpt
For most associations of common single nucleotide polymorphisms (SNPs) with common diseases, the genetic model of inheritance is unknown. The authors extended and applied a Bayesian meta-analysis approach to data from 19 studies on 17 replicated associations with type 2 diabetes. For 13 SNPs, the data fitted very well to an additive model of inheritance for the diabetes risk allele; for 4 SNPs, the data were...
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