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Article

Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.

Journal of epidemiology - 5 Jan 2018

Kodama Satoru, Fujihara Kazuya, Ishiguro Hajime, Horikawa Chika, Ohara Nobumasa, Yachi Yoko, Tanaka Shiro, Shimano Hitoshi, Kato Kiminori, Hanyu Osamu, Sone Hirohito

Abstract excerpt

Many epidemiological studies have assessed the genetic risk of having undiagnosed or of developing type 2 diabetes mellitus (T2DM) using several single nucleotide polymorphisms (SNPs) based on findings of genome-wide association studies (GWAS). However, the quantitative association of cumulative risk alleles (RAs) of such SNPs with T2DM risk has been unclear. The aim of this meta-analysis is to review the...

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PMID: 29093303
DOI: 10.2188/jea.JE20160151
PMCID: PMC5742374

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