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Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

30 Jul 2024

Abstract excerpt

The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers. This phenomenon has been investigated since the late 1980s without resolution. Expanding beyond previous gene-centric studies, we investigated the co-occurrence in a genome-wide manner, taking an evolutionary perspective. Mining of large-scale tumor aneuploidy data confirmed...

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PMID: 39078448
DOI: 10.1158/0008-5472.can-24-1366

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