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Article

Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways.

Molecular biology and evolution - 1 Nov 2009

Brown Kyle M, Depristo Mark A, Weinreich Daniel M, Hartl Daniel L

Abstract excerpt

Understanding the molecular details of the sequence of events in multistep evolutionary pathways can reveal the extent to which natural selection exploits regulatory mutations affecting expression, amino acid replacements affecting the active site, amino acid replacements affecting protein folding or stability, or variations affecting gene copy number. In experimentally exploring the adaptive landscape of the...

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PMID: 19602543
DOI: 10.1093/molbev/msp151
PMCID: PMC2912465

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