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Article

Molecular Clock of Neutral Mutations in a Fitness-Increasing Evolutionary Process.

PLoS genetics - 1 Jul 2015

Kishimoto Toshihiko, Ying Bei-Wen, Tsuru Saburo, Iijima Leo, Suzuki Shingo, Hashimoto Tomomi, Oyake Ayana, Kobayashi Hisaka, Someya Yuki, Narisawa Dai, Yomo Tetsuya

Abstract excerpt

The molecular clock of neutral mutations, which represents linear mutation fixation over generations, is theoretically explained by genetic drift in fitness-steady evolution or hitchhiking in adaptive evolution. The present study is the first experimental demonstration for the molecular clock of neutral mutations in a fitness-increasing evolutionary process. The dynamics of genome mutation fixation in the thermal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26177190
DOI: 10.1371/journal.pgen.1005392
PMCID: PMC4503671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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